For an oocyte to get All set for fertilization and growth into an embryo, the best list of genes should be turned on. Namekawa suspected that this pre-programming of the oocyte genome happens in a number of phases — the very first just one beginning within the time a feminine is born. He thought that chromatin remodeling proteins did A lot of the work, by shifting spools all around.
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Using the GCRLE grant, Munakata and Namekawa will search extra carefully at how oocytes are genomically primed and stored for later on use. They're going to investigate the purpose of the chromatin remodeler in oocyte survival and fertility.
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Huge protein machines, known as chromatin remodelers, can shift the positions of spools up and down the DNA thread, therefore facilitating the expression — or silencing — of A large number of genes.
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